This medicine is used in women who have finished menopause for treatment of early breast cancer. It is used in the following areas:
• after surgery, with or without radiation
• in women whose breast cancer is hormone receptor-positive
• first treatment of locally advanced or metastatic breast cancer in women whose breast cancer is hormone receptor-positive or the hormone receptors are not known
• treatment of advanced breast cancer, if the cancer has grown, or the disease has spread after tamoxifen therapy

This medicine does not work in women with breast cancer who have not finished menopause (premenopausal women).

Take this medicine exactly as prescribed by your doctor. Keep taking this medicine for as long as your doctor prescribes it for you.

Take one tablet each day with or without food. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Take your next regularly scheduled dose. Do not take two doses at the same time.

If you have taken more this medicine than your doctor has prescribed, contact your doctor right away. Do not take any additional this medicine until instructed to do so by your doctor.

Talk with your doctor about any health changes you have while taking this medicine.

Get medical help right away if you have any allergic reactions including skin lesions, ulcers, blisters, or swelling of the face, lips, tongue, or throat. This medicine can cause serious side effects including increased blood cholesterol (fat in the blood).

This medicine can cause inflammation of the liver and changes in blood tests of the liver function. Your doctor may monitor you for this. Stop taking this medicine and call your doctor right away if you have any of these signs or symptoms of a liver problem:
• a general feeling of not being well
• yellowing of the skin or whites of the eyes
• pain on the right side of your abdomen

Common side effects in women taking this medicine include:
• hot flashes
• weakness
• joint pain
• carpal tunnel syndrome (tingling, pain, coldness, weakness in parts of the hand)
• pain
• sore throat
• mood changes
• high blood pressure
• depression
• nausea and vomiting
• thinning of the hair (hair loss)
• rash
• back pain
• sleep problems
• bone pain
• headache
• swelling
• increased cough
• shortness of breath
• lymphedema (build up of lymph fluid in the tissues of your affected arm)
• trigger finger (a condition in which one of your fingers or your thumb catches in a bent position)

Call your doctor for medical advice about side effects.

Do not take this medicine if you:
• have not finished menopause (are premenopausal)
• are allergic to any of the ingredients in this medicine
• are a man or child

Stop taking this medicine and call your doctor right away if you have chest pain or shortness of breath. These can be symptoms of heart disease.

Women with early breast cancer, who have a history of blockages in heart arteries (ischemic heart disease) and who take this medicine may have a slight increase in this type of heart disease compared to similar patients who take tamoxifen.

This medicine lowers estrogen in your body, which may cause your bones to become softer and weaker (osteoporosis).This can increase your chance of fractures, specifically of the spine, hip and wrist.
Your doctor may order a test for you called a bone mineral density study before you start taking this medicine and during treatment with this medicine as needed.

Before taking this medicine, tell your doctor about all your medical conditions, including if you:
• have not finished menopause
• have had previous heart problems
• have a condition called osteoporosis
• have high cholesterol

Know the medicines you take. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

This medicine may not work if taken with one of these medicines:
• tamoxifen
• hormone replacement therapy
• birth control pills
• estrogen creams
• vaginal rings
• vaginal suppositories

FDA pregnancy category C. This medicine may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether this medicine passes into breast milk or if it could harm a nursing baby. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

The above information is provided to the best of our knowledge and in good faith, it is without a warrant of any kind, expressed or implied.